VAGINAL/RECTAL OZONE SUPPOSITORY

Each Biome and Beyond ozone suppository holds 2.6 mL of fully ozonated olive oil, and a proprietary blend of clincally proven essential oils and probiotics.

Comes in jars of 30.

Ingredients: Fully ozonated organic olive oil, organic cocoa butter, medical grade ozone, Lemongrass Essential Oil, Thyme Essential Oil, Lavender Essential Oil, Bacillus Coagulans probiotic.

Different oils hold different amounts of ozone. This is determined using the potential ozonide intensity factor. This is measured by looking at the omega 3, 6, 9 fatty acids that the particular oil holds. Oils with higher omega 9 fatty acids hold more ozone. Olive oil is roughly in the middle of the potential ozonide intensity scale.

We recommend storing ozone suppositories in the refrigerator so they will last longer and are easier to use. Ozonated oil has been known to last over ten years when refrigerated. It is highly recommended placing into a refrigerator immediately upon receiving to help preserve freshness.

THE FORMULA

Ozonated Olive Oil

Human studies that compared Ozonated olive oil to prescription antifungal creams, suggested Ozonated olive oil as a safe and effective natural alternative to these drugs. Especially in cases of vaginal yeast infections.

Results • Ozone and clotrimazole both reduced symptoms significantly and led to a negative culture for vaginal candidiasis (P < .05). No significant differences existed between the 2 groups in their effects on the symptom of itching and leucorrhea and on the results of the culture (P > .05).

Ozonated olive oil was also shown to be gentle enough for cases of mouth irritation and gum infections and various skin issues.

LEMONGRASS ESSENTIAL OIL

Lemongrass contains several biocompounds in its decoction, infusion and essential oil extracts. It is an Anti-oxidant, anti-inflammatory, anti-bacterial, anti-fungal, anti-obesity, antinociceptive, anxiolytic and antihypertensive. Evidences of lemongrass were clearly elucidated to support initial pharmacological claims. In addition Lemongrass is non-toxic and non-mutagenic.

In one study, The antibacterial and antifungal activity of ten essential oils was tested against a range of vaginal bacterial and fungal strains isolated from existing vaginal infections including Atopobium vaginae, Gardnerella vaginalis, Bacteroides vulgatus, Streptococcus agalactiae, H2O2-producing lactobacilli and non H2O2-producing lactobacilli, Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis. Investigation of the in vitro susceptibility of the essential oils against bacteria revealed that lemongrass, tea tree and lavender exhibited the lowest minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) at 1-2.5 μl/ml, thus being the most potent essential oils against the tested bacteria.

THYME ESSENTIAL OIL

Bacterial vaginosis (BV) is the most frequent diagnosis made in women with lower genital tract symptoms. It has recently been observed that 90 % of subjects with BV show the growth of bacteria in the form of biofilms as against only 10% without BV, and that Gardnerella vaginalis was the predominant species. The propensity of G. vaginalis to form biofilm is clinically relevant because this form of growth allows it to tolerate higher concentrations of certain antibiotics, thus increasing the possibility of recurrent BV even after apparently curative therapy. One study found that thymol, a molecule present in thyme essential oil, is credited with having a series of pharmacological properties including antimicrobial and antifungal effects, can interfere with newly formed and mature G. vaginalis biofilms.

LAVENDER ESSENTIAL OIL

The treatment of candidiasis infections is an important problem in the health care system. One study investigated the in vitro effect of lavender essential oil and clotrimazole(pharmaceutical antifungal) on isolated C. albicans from vaginal candidiasis. At 48 hours the average fungal cell count was lower in lavender group. In addition, the lavender had no negative impact on the healthy vaginal flora while the clotrimazole has a deleterious effect on the beneficial bacteria.

BACILLUS COAGULANS

Disruption of vaginal microbiota equilibrium promotes infectious clinical syndromes with annoying symptoms, such as vaginal discharge, odour, irritation, pruritus, and vulvar burning. Although identifying and eradicating the pathogen involved has been the standard of care, regional microbiota restoration with probiotics has been gaining ground in recent years. This study aimed to assess the effectiveness of topical Bacillus coagulans treatment for patients exhibiting vaginal discomfort symptoms. A clinical trial was conducted on the use of a topical B. coagulans regimen among reproductive-age women with vaginal discomfort symptoms. We assessed their symptoms using a questionnaire, measured vaginal pH, and performed vaginal swabs for microscopy and cultivation. Over the next 4 days, patients received B. coagulans vaginal douches and suppositories with appropriate antibiotic treatment being added on the fourth day based on vaginal swab results. Patients returned 16 days later to fill out in the questionnaire again. The Wilcoxon signed-ranked test was then used to assess differences in symptomatology and pH between appointments. A reduction in vaginal pH was reported between the first and second visit (P<0.001). The probiotic regimen exerted a major beneficial effect in all vaginal manifestations: vulvovaginal itching, burning sensation, vaginal irritation, and vaginal discharge. Additionally, three out of the four symptoms were alleviated to a greater extent during the first four days of exclusive probiotic use than during the second phase. Our sample provided significant results regarding the benefits of B. coagulans for vaginal discomfort. We postulate that the greatest symptom improvement was achieved within the first 4 days of exclusive probiotic use, before the addition of antibiotics. This study agrees with the increasing literature on the contribution of probiotics toward vaginitis treatment.

In addition, B. subtilis reduced the biofilm formation and filamentation of C. albicans by negatively regulating the ALS3, HWP1, BCR1, EFG1 and TEC1 genes that are essential for the production of biofilm and hyphae.

FAQ's

Q. What does this treat?

A. This Product is designed to treat many pathological infections of the female reproductive tract. Specifically, we have aimed at creating a product to effectively eliminate vaginal yeast infections, Candida overgrowth, Acute and Chronic Bacterial Vaginosis, and any other type of vaginal dysbiosis. We have also seen good results in those individuals suffering from viral infections associated with Genital Herpes (Herpes Simplex 2) and HPV (Human Papilloma Virus).

Q. Does the product have a scent?

A. The product incorporates the essential oils of Lavender, Lemongrass and Thyme. so any aversion to those oils would be contraindicated regarding the smell. The vast majority report that they like the scent and it is not overpowering. We DO NOT use any synthetic perfumes or fragrances which tend to be toxic and unpleasant.

Q. Can it be used Daily?

A. We recommend Daily use for anyone dealing with an acute or chronic infection. The suppository is best inserted before bedtime to ensure placement. On average we recommend 12 to 15 days of daily use during the infection period and that can be continued if the symptoms persist.

Q. Can this be used preventatively?

A. We believe that less is more and if the reproductive tract is balanced and healthy then we do not recommend daily use. Best if used during those times of imbalance or during periods with active and/or known infections.